Skyline Extruder Spheronizer
Name of Machine:
Skyline Extruder Spheronizer
Available Capacity Range: 1 kg to 100 kg per hour
The Skyline Extruder Spheronizer is a critical system in the pharmaceutical industry for producing uniform, spherical pellets essential for controlled-release and sustained-release drug formulations. The process begins by preparing a wet mass of the API and excipients, which is then extruded through a die to form cylindrical extrudates. These extrudates are cut into uniform segments and transferred to the spherometer, where they are rounded into spheres by a rapidly rotating disc inside a cylindrical chamber.
Key parameters—including moisture content, extrusion speed, and spherization time—are precisely controlled to ensure consistent pellet size, shape, and density. This precision is crucial for predictable drug release profiles and optimal bio-availability. The technology supports high-quality, scalable, and versatile multi-particulate systems, contributing to improved therapeutic efficacy and patient compliance.
Salient Features
- Variable Speed Control: Enables precise adjustment of
extrusion speed to optimise extrude quality and consistency.
- Interchangeable Dies: Various die plates with
different hole sizes and shapes allow production of pellets with multiple
diameters and profiles.
- Robust Screw Design: Available in single or
twin-screw configurations, designed for high torque, minimal wear, and
consistent material flow.
- Temperature Control: Integrated heating or cooling
systems maintain optimal processing conditions, essential for
heat-sensitive formulations.
- Automatic Feeding System: Provides continuous, uniform
feeding of wet mass, reducing manual intervention and ensuring consistent
output.
