Skyline Vibro Sifter
Skyline Extruder Spheronizer
Capacity : 1 Kg to 100 Kg/Hr.
The Skyline Extruder Spheronizer is a critical system in the pharmaceutical industry for producing uniform, spherical pellets essential for controlled-release and sustained-release drug formulations. The process begins by preparing a wet mass of the API and excipients, which is then extruded through a die to form cylindrical extrudates. These extrudates are cut into uniform segments and transferred to the spherometer, where they are rounded into spheres by a rapidly rotating disc inside a cylindrical chamber.
Key parameters—including moisture content, extrusion speed, and spherization time—are precisely controlled to ensure consistent pellet size, shape, and density. This precision is crucial for predictable drug release profiles and optimal bio-availability. The technology supports high-quality, scalable, and versatile multi-particulate systems, contributing to improved therapeutic efficacy and patient compliance.
Key parameters—including moisture content, extrusion speed, and spherization time—are precisely controlled to ensure consistent pellet size, shape, and density. This precision is crucial for predictable drug release profiles and optimal bio-availability. The technology supports high-quality, scalable, and versatile multi-particulate systems, contributing to improved therapeutic efficacy and patient compliance.
Salient Features
- Variable Speed Control: Enables precise adjustment of
extrusion speed to optimise extrude quality and consistency.
- Interchangeable Dies: Various die plates with
different hole sizes and shapes allow production of pellets with multiple
diameters and profiles.
- Robust Screw Design: Available in single or
twin-screw configurations, designed for high torque, minimal wear, and
consistent material flow.
- Temperature Control: Integrated heating or cooling
systems maintain optimal processing conditions, essential for
heat-sensitive formulations.
- Automatic Feeding System: Provides continuous, uniform feeding of wet mass, reducing manual intervention and ensuring consistent output.
Spheroizer Features
- Adjustable Rotational Speed: Allows fine-tuning of dics speed for optimal
pellet rounding and surface finish.
- Variable Disc Textures: Smooth, grooved, or ribbed
disc surfaces available to achieve desired spherization efficiency and
pellet quality.
- Time Control: Programmable process duration ensure uniform
pellet size and shape across batches.
- Easy-Clean Design: Components are engineered for
quick disassembly and cleaning, minimising cross-contamination and
ensuring GMP compliance.
- Integrated Cooling: Controls heat
generated during spherization, protecting temperature- sensitive ingredients and
maintaining pellet integrity.
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